In anaphylaxis treatment, what is the immediate pharmacologic intervention?

• A. Transport
• B. Administer Epinephrine 1:1000
• C. History, physical, vitals
• D. Consider albuterol

Answer: (B)

Immediate pharmacologic intervention in anaphylaxis is administering epinephrine 1:1000 intramuscularly. Anaphylaxis can rapidly cause airway swelling and bronchospasm leading to shock, so epinephrine is used right away because it works on multiple body systems to reverse these life-threatening effects. Its alpha-1 action causes vasoconstriction to reduce airway swelling and support blood pressure, its beta-2 action bronchodilates to open the airways, and its beta-1 action improves cardiac output. This rapid reversal is why epinephrine is the first move in treatment. After giving epinephrine, continue with transport and supportive measures; albuterol may help persistent bronchospasm, but it does not replace the need for epinephrine.